| 摘要 |
Cells, esp. haematopoietic cells, which are trapped with regard to activation, by an antigen (Ag), against which tolerance of the host (animal or human) immune system is sought, contain a genetic sequence (I), the expression product (II) of which, when produced at a high level in the cells, reacts in situ with a pharmaceutically active substance (III) to induce cell destruction. The cell also includes elements, specifically induced by an activation signal provided by Ag, so as to cause high level prodn. of (II). Pref. (I) and the necessary control elements are present on a recombinant DNA fragment specifically, the elements are those which normally control expression of a cytokine (esp. IL-2) or the corresponding receptor. (III) cause, directly or indirectly, interruption of cellular DNA replication. |
