Pantothensäure Derivate.

摘要

Compounds represented by general formula (I) below wherein R<1> and R<2>, which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group; R<3> represents a saturated or unsaturated, linear, branched or cyclic, monovalent C5 SIMILAR C25-aliphatic hydrocarbon group which may be substituted with an aromatic group, or a group of formula where R<4> represents a saturated or unsaturated, linear, branched or cyclic, monovalent C5 SIMILAR C25-aliphatic hydrocarbon group which may be substituted with an aromatic group, and R<5> represents a hydrogen atom, or a saturated or unsaturated, linear, branched or cyclic, monovalent hydrocarbon group which may be substituted with an aromatic group; Q represents (a) a group of formula -X<1>-A-Y<1>-, where A represents a saturated or unsaturated, linear, branched or cyclic divalent C2 SIMILAR C16-aliphatic hydrocarbon group which may be substituted with an aromatic group, a divalent aromatic hydrocarbon group or a divalent aromatic heterocyclic group; one of X<1> and Y<1> represents and the other represents -O-, -S- or in which R<6> and R<7> each represent a hydrogen atom or a lower alkyl group; (b) a group of formula -X<2>-(CH2) l -Y<2>-, where one of X<2> and Y<2> represents a group of formula and the other represents -O-, -S- or represents a 4 SIMILAR 7-membered, divalent nitrogen-containing aromatic heterocyclic group, and R<6> has the same meaning as defined above, and l is 0, 1 or 2; or (c) a group of formula where m is 2 or 3; n is an integer of from 1 to 4. The compounds have excellent inhibitory activity against acyl Co A-cholesterol-acyltransferase.