New 1,2-cycloalkeno-pyridine derivs.

摘要

1,2-Cycloalkeneopyridine derivs. of formula (I) are new: A = (CR5R6)n; n = 1-8; R1 = H, 1-10C alkyl, 1-10C alkoxy, 3-8C cycloalkoxy,etc.; R2 = H, 1-4C alkyl, 3-8C cycloalkyl, 1-10C alkoxy, 3-8C cycloalkoxy, 2-11C alkoxycarbonyl,etc.; or R1+R2 = CH2(CH2)mCH2;m = 1-3; R3-R8 = H, 1-10C alkyl, 1-10C alkoxy,etc.;X = O, S, NH or NR; R = 1-10C alkyl, 2-10C alkenyl,etc.;Y = a bond or a 1-6C divalent hydrocarbon gp.,etc.; Z = (a) aryl or O-aryl, where aryl is defined as phenyl opt. substd. by halo, 3-8C cycloalkyl,etc.; or (b) 3-8C cycloalkyl, 2-7C azacycloalkyl (contg. NR1), 5-8C cycloalkenyl or 4-7C azacyloalkenyl (contg. NR1), all opt. substd. by 1-18C alkyl, 2-18C alkenyl, 1-12C alkoxy, 1-12C alkanoyloxy, 2-12C acyl, 2-13C alkoxycarbonyl,etc.; provided that when n = 2, R1 = Me, R2-R8 = H, X = NH, Y = a bond and Z = 4-t-butylcyclohexyl, the t-butyl gp. is cis.