发明名称 |
PROCESS FOR INCREASING THE ANTAGONISTIC EFFECT OF PEPTIDIC COMPOUNDS ON HORMONE-DEPENDENT DISEASES |
摘要 |
The antagonistic effect of the releasing hormone of LH and FSH or of one of its synthetic analogues selected from the group (pyro) Glu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 (pyro) Glu-His-Trp-Ser-Tyr-D-Phe-Leu-Arg-Pro-Gly-NH2 and (pyro) Glu-His-Trp-D-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHR1 (R1 being an alkyl group) on hormone-dependent diseases can be increased by coating such compounds by micro-encapsulation or by matrix formation with a copolymer of a lactide and a glycolide. The initial stimulating effect of the above-mentioned compounds is increased by this coating, with about 23 to 50% of the active principle of the analog being released within about 1-5 days after injection to a human, with the remainder released over a period of between about 3 weeks and two months.
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申请公布号 |
CA1335711(C) |
申请公布日期 |
1995.05.30 |
申请号 |
CA19880566908 |
申请日期 |
1988.05.16 |
申请人 |
DEBIOPHARM, S.A. |
发明人 |
TICE, THOMAS R.;SCHALLY, ANDREW V.;ORSOLINI, PIERO |
分类号 |
A61K9/52;(IPC1-7):A61K37/43 |
主分类号 |
A61K9/52 |
代理机构 |
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地址 |
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