发明名称 DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS
摘要 The compounds of formula (I) wherein R1 and R2 are, independently, hydrogen, straight or branched chain alkyl or mono- or bi-cyclic alkyl; A is an N-heterocycle which may be substituted by alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, amino, alkylamino, dialkylamino, alkylsulfonamido, alkylcarboxamido, nitro, cyano or carboxyl; or, A is a substituted phenyl group containing one or two substituents selected from cyano, nitro, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, amino, alkylamino, dialkylamino, sulfamyl, alkylsulfonamido, arylcarboxamido, alkylsulfonyl, perfluoroalkylsulfonyl, arylsulfonyl, chloro, bromo, fluoro, iodo, 1-imidazolyl or carboxyl; or a pharmaceutically acceptable salt thereof, are smooth muscle relaxants.
申请公布号 WO9514005(A1) 申请公布日期 1995.05.26
申请号 WO1994US12561 申请日期 1994.11.01
申请人 AMERICAN HOME PRODUCTS CORPORATION 发明人 BUTERA, JOHN, ANTHONY;ANTANE, SCHUYLER, ADAM
分类号 A61K31/395;A61K31/415;A61K31/44;A61K31/4406;A61K31/4409;A61K31/47;A61K31/472;A61P9/08;A61P11/08;C07C255/50;C07C255/58;C07C311/43;C07D213/74;C07D215/38;C07D215/40;C07D215/42;C07D217/02;C07D231/56 主分类号 A61K31/395
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