摘要 |
The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I <IMAGE> and pharmaceutically acceptable salts thereof wherein A stands for C1-4 alkylene and R1 represents C1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C5-6 cycloalkyl or aminoalkyl of the Formula -(CH2)n-NR2R3 in which group n is an integer 1-3; R2 and R3 each stand for hydrogen or C1-4 alkyl or together with the adjacent nitrogen atom they are attached to form a 5- or 6-membered nitrogen containing heterocyclic ring which may optionally comprise a further nitrogen atom or an oxygen atom as heteroatom; or R1 stands for phenyl, hydroxyphenyl, carboxyphenyl, benzyl or dimethoxybenzyl The compounds of the Formula I can be prepared by methods known per se and can be used in therapy as antitussive agents. |
申请人 |
CHINOIN GYOGYSZER-ES VEGYESZETI TERMEKEK GYARA RT |
发明人 |
KORBONITS,DEZSO;MINKER,EMIL;VARGAI,ZOLTAN;HEJA,GERGELY;KOVACS,GABOR;GOTTSEGEN,AGNES;ANTUS,SANDOR;VIRAG,SANDOR;BOLEHOVSZKY,ANDREA;MARTON,JENO;MARMAROSI,KATALIN;DEBRECZENI,LORAND;TARDOS,LASZLO;KORMOCZY,PETER;GERGELY,VERA;HORVATH,GABOR |