Recombinant varicella-zoster virus and process for constructing same

摘要

The present invention provides a recombinant varicella-zoster virus prepared by inserting at least one kind of gene selected from a gene group of hepatitis B virus genome, a genomic DNA of said recombinant virus, a live vaccine containing said recombinant virus as an effective ingredient, an antigen originating from said recombinant virus, and diagnostic agent containing said antigen. The recombinant varicella-zoster virus of the present invention can be utilized as a multivalent vaccine having an excellent immunity effect both on chickenpox and hepatitis B, and the expression products and genomic DNA thereof may be used as a multivalent diagnostic agent.