| 摘要 |
<p>A preservative-free ophthalmic composition is disclosed which is useful in the treatment of conditions such as dry eye and which comprises an aqueous solution of (a) about 0.20 to 2.5 weight percent of a polymer selected form the group consisting of hydroxyalkyl cellulosics and polyalkylene glycols; (b) a non-ionic tonicity adjusting agent selected from the group consisting of mannitol, sorbitol, dextrose, sucrose, urea, glycerol, and mixtures thereof, in a amount sufficient to generate a tonicity of about 50 to 350 milliosmols per kilogram (mOsmol/kg); (c) an ionic salt which is preferably an alkali metal halide, in an amount sufficient to approximate the salt concentration of the human tear fluid; and (d) an antimicrobial in an amount sufficient to generate sufficient borate to maintain or reduce microbial concentrations for a period of 12 hours to 72 hours.</p> |
