Slow release compositions

摘要

PCT No. PCT/GB91/01452 Sec. 371 Date Apr. 21, 1993 Sec. 102(e) Date Apr. 21, 1993 PCT Filed Aug. 29, 1991 PCT Pub. No. WO92/04032 PCT Pub. Date Mar. 19, 1992.Lithium titanate is made by heating to a temperature of at least 715 C., powder form lithium carbonate and titanium dioxide while mixing, for instance in a rotary kiln. The product is formulated into extended release oral pharmaceutical compositions. Lithium ions are released by zero order rate characteristics from the compositions. The composition can have increased density to extend retention in the stomach. The compositions are used for treatment of manic depressive illness.