| 摘要 |
<p>where:- R' = alkyl (1 to 6C atoms) R" = H or alkyl (1 to 6C atoms) X and X' = one or more of the following - H, alkyl (1 to 6C atoms), alkenyl (1 to 6C atoms), Halogen, trifluoromethyl, OH, alkoxy (1 to 4C atoms), mercapto, alkylmercapto (1 to 4C atoms), alkyl-sulphonyl (1 to 4C atoms), sulphamoyl, alkylsulphamoyl (1 to 4C atoms), dialkylsulphamoyl (1 to 8C atoms). R' and R" can also represent a heterocyclic ring (5 or 6 atoms) connected via a C, N, or O atom, such as 1-piperidyl, 1-pyrrolidyl, 4-morpholinyl, and 1-(lower alkyl)-4-piperazinyl. Z = H, OH, OY, = NOR deg., = NOY, NH2, NHSO2R, NR deg. R"'. = NNH2 or the groups represented by (II) and (III). In addition, when Z = H, OH, or OY, the other H atom at position 11 can be R"', In the above values for Z, R deg. = H, alkyl (1 to 6 C atoms), R"' = alkyl (1 to 6 C atoms) n = 0, 1, 2, or 3. B = H, halogen, CF3, alkyl (1 to 4 C atoms), alkoxy (1 to 4 C atoms). Y = saturated or unsaturated alkanoyl group (1 to 18 C atoms). In the formula (I), the propyl side chain may be substituted with a lower alkyl group (1 to 4 C atoms). (B) Pharmaceutical preparations containing (I), and the medically accepted acid addition salts of (I). The compounds have antidepressive activity.</p> |
