BINDING COMPETENT OLIGOMERS CONTAINING UNSATURATED 3',5' AND 2',5' LINKAGES

摘要

Oligonucleotide analogs having one or more substitute linkages of the formula 2'/3' -S-CH2-CH=5' or 2'/3' -O-CH2-CH=5' between adjacent nucleomonomers are disclosed. The substitute linkage replaces the usual phosphodiester linkage found in unmodified nucleic acids. The oligonucleotide analogs are easy to synthesize, stable in vivo, resistant to endogenous nucleases and are able to hybridize to target nucleic acid sequences in a sequence specific manner.