3'-PHOSPHONONUCLEOSIDE COMPOUNDS AND METHOD FOR PREPARING SAME

摘要

A method for preparing a compound of formula (Ia), wherein B is a purine or pyrimidine base, X is H or OH, and Y is H, OH or CH3, by (1) condensation reacting a pentose compound (II) with a protected purine or pyrimidine base B' to give a protected compound (I') in accordance with formulae (II) and (I'), wherein X' is H or OR'', where R'' is an OH function protective grouping, B' is the base B with optionally protected exocyclic functions NH2, Z is a leaving group such as a halogen or an OR group, and R and R' are OH function protective groupings; and (2) deprotecting the compound (I').