alpha nucleoside compounds and a method for treating HBV using said compounds

摘要

A compound of the formula wherein the radicals A, X, R1, R2 and R3 are defined as follows: A: (a) (b) X: (a) O (b) S (c) CH2 R1: H; alkyl containing 1-3 carbon atoms; -CH=CH2; -CH=CH-CH3; -CH2-CH=CH2; -C 3BOND CH p1 R2: H; or R2 constitutes together with R3 a carbon-carbon bond R3: H; F; Cl; Br; I; N3; CN; C 3BOND CH; OH; OCH3; CH2OH; and when R3 is F; Cl; Br; I; N3; CN; C 3BOND CH; OH; OCH3 or CH2OH it may have either the cis-configuration or trans-configuration relative to the hydroxymetyl function at position 4', or R3 constitutes together with R2 a carbon-carbon bond, and therapeutically acceptable salts thereof, for use in therapy, in particular for the treatment of HIV virus infections.