2-(1-ALKOXY-2-NAPHTHALENYL)-PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE D3 RECEPTOR ANTAGONISTS

摘要

Compounds of formula (I), wherein R<1> represents C1-4alkyl; R<2> represents hydrogen, halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, C1-4alkylsulphonyl, trifluoromethylsulphonyl; optionally substituted arylsulphonyl, optionally substituted heteroarylsulphonyl, optionally substituted aralkylsulphonyl, optionally substituted heteroaralkylsulphonyl, nitro, cyano, amino, mono- or di-C1-4alkylamino, trifluoromethyl, trifluoromethoxy, hydroxy, hydroxyC1-4alkyl, C1-4alkylthio, C1-4alkanoyl, C1-4alkoxycarbonyl, aminosulphonyl, C1-4alkylaminosulphonyl or di-C1-4alkylaminosulphonyl; and Y represents a group selected from (a), (b), (c) or (d), wherein in group (a): R<3> and R<4> independently represent hydrogen, C1-6alkyl, optionally substituted arylC1-6alkyl or optionally substituted hetereoarylC1-6alkyl; R<5> represents C1-6alkyl, C3-6alkenyl or C3-6cycloalkylC1-4alkyl; and R<6> represents C1-6alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl, optionally substituted arylC1-4alkyl or optionally substituted heteroarylC1-4alkyl; or NR<5>R<6> forms a heterocyclic ring; in group (b): R<7> represents C1-6alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl, optionally substituted arylC1-4alkyl or optionally substituted heteroarylC1-4alkyl; and q is 1 to 4; in group (c): R<8> and R<9> independently represent hydrogen, C1-6alkyl, optionally substituted arylC1-6alkyl or optionally substituted heteroarylC1-6alkyl; R<10> represents an optionally substituted aryl or optionally substituted heteroaryl group; and Z represents -(CH2)r wherein r is 2 to 8 or -(CH2)sCH=CH(CH2)t where s and t independently represent 1 to 3; and in group (d): each of m and n independently represents from 1 to 3; and salts thereof, have activity at dopamine receptors and are potentially useful in the treatment of psychoses such as schizophrenia, and intermediates of formulae (II), (VII) and (VIII).