| 摘要 |
A polypeptide represented by formula (I), [in which: A1 is an amino acid or a peptide having one or at least two basic amino acids selected from lysine, arginine and ornithine, said amino acid or peptide in which amino terminal N- alpha may be replaced with an acyl group or a substituted thiocarbamoyl group; A2 is a tyrosine or phenylalanine; A3 is a lysine or arginine; A4 is an -OH or an -NH2; and X is a peptide such as D-ornithyl-proline, prolyl-D-ornithine, D-lysyl-proline, prolyl-D-lysine, D-arginyl-proline, prolyl-D-arginine, glycyl-ornithine, ornithyl-glycine, glycyl-lysine, lysyl-glycine, glycyl-arginine and arginyl-glycine, in which the hydrogen atom of the omega -amino group of D-lysine, L-lysine, D-ornithine and L-ornithine may be replaced by an omega -amino acyl group, and said peptide is connected to the amino acid residues at the 6th and the 8th positions via peptide bond per se; Trp is a tryptophan; and Cys is a cysteine], and one example of such polypeptide be represented as formula (1) is presented. The above presented polypeptide may be useful in a pharmaceutical composition as an antimicrobial or antiviral agent, specifically as an anti-HIV agent and as a component of the DNA-transfecting systems for gene therapy.
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