摘要 |
The invention herein provides bleaching compositions comprising a protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions correspond to naturally-occurring subtilisin from <u>Bacillus amyloliquefaciens</u> or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as <u>Bacillus lentus</u> subtilisin) and a bleaching agent. |
申请人 |
THE PROCTER & GAMBLE COMPANY |
发明人 |
BURNS, MICHAEL, EUGENE;GHOSH, CHANCHAL, KUMAR;DIGIULIO, DAVID, NEIL;GETTY, EDWARD, EUGENE;WILLEY, ALAN, DAVID;HARTSHORN, RICHARD, TIMOTHY;BRODE, PHILIP, FREDERICK, III;BARNETT, BOBBY, LEE;RUBINGH, DONN, NELTON |