Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)

摘要

The invention relates to compounds (I) for treating diseases of the central and peripheral nervous system, including enantiomers, racemates and acid addition and quaternary salts, <IMAGE> (I) wherein Q is selected from two H atoms, (CH2)m and C(CH3)2 where m is 1, 2 or 3 and n and p are; each independently 0, 1, 2 or 3, provided that n+p=1-3, and R0 is H, methyl or OH; the moiety <IMAGE> R is selected from H, NH2, NH-C1-6-alkyl, N(C1-6-alkyl)2, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C3-7- cycloalkyl, C1-6-alkyl substituted by 1-6 halogen atoms, hydroxy- C1-6-alkyl, C1-6-alkoxy, C1-6-alkylthio, C1-6-alkoxy-C1-6-alkyl, carboxy-C1-6-alkyl, (C1-6-alkoxy)carbonyl-C1-6-alkyl, amino-C1-6-alkyl, mono-(C1-6-alkyl)amino-C1-6-alkyl, di-(C1-6-alkyl)amino-C1-6-alkyl, 2-oxo-pyrrolidin-1-yl-methyl, aryl, diarylmethylol, and C1-6-alkyl substituted by one or two aryl groups; R' is independently selected from the group from which R is selected and C1-6-alkanoyl and arylcarbonyl; and aryl denotes unsubstituted phenyl or phenyl substituted by 1-3 substituents selected from halogen, C1-6-alkyl, C1-6-alkoxy and CF3, subject to certain provisos.