PROCESS AND INTERMEDIATES FOR THE ENANTIOSPECIFIC SYNTHESIS OF BENZO [D]NAPHTH[2,1-B]AZEPINES

摘要

Disclosed are a process and intermediates of formula (1) wherein R is -CH3 or -C(O)-OR?1, and R1 is C¿1-C6 alkyl or -CH2C6H5; or formula (2) wherein: R2 is H or OH, R is -C(O)OR?1 and R1 is C¿1-C6 alkyl or -CH2C6H5, or where R2 is H, R can also be CH¿3?; for preparing benzazepine intermediates of formula (3). The benzazepine intermediates are useful for preparing benzazepines having activity as selective D1 receptor antagonists.