发明名称 |
Taga gene and methods for detecting predisposition to peptic ulceration |
摘要 |
The present invention provides an isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also provides methods of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of contacting an antibody-containing sample from the subject with a detectable amount of the tagA antigen or antigenic fragment of the present invention and detecting the reaction of the antigen or fragment and the antibody. A mutant H. pylori not expressing a functional tagA antigen is also provided.
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申请公布号 |
US5403924(A) |
申请公布日期 |
1995.04.04 |
申请号 |
US19930053614 |
申请日期 |
1993.04.26 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
COVER, TIMOTHY L.;TUMMURU, MURALI K. R.;BLASER, MARTIN J. |
分类号 |
G01N33/53;A61K38/00;A61K39/395;A61P1/04;C07H21/04;C07K14/195;C07K14/205;C07K16/12;C12N1/21;C12N15/09;C12P21/02;C12P21/08;C12Q1/68;C12R1/01;C12R1/19;G01N33/569;(IPC1-7):C07H21/02 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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