| 摘要 |
Described is a rectally administered composition for inhibiting epileptic seizure and its methods of use. The composition contains, in a suitable solvent, an anti-epileptic agent for inhibiting epileptic seizure, a buffer for maintaining pH, and a thickener for imparting a viscosity to the composition effective for rectal administration by injection to a patient in epileptic seizure. Also described is an applicator (10) for the rectal delivery of a medication, e.g., the above described composition, and a method of using the applicator (10). The applicator (10) has a shroud (20) with a longitudinal barrel (30). A cartridge (50) is insertable within the barrel (40), and there are projections (75) for holding the cartridge (50) within the barrel (40). The shroud (20) is made of a plastic material which may have a lubricating additive. The nozzle (30) of the applicator (10) is tapered for delivery of the medication. A seal pin (80) is insertable within a boss (57) of the cartridge (50) to seal the medication from leakage. A tray (21) holds the applicator (10) and lubricant (22). |
