发明名称 |
Multi-unit ribozyme inhibition of oncogene expression |
摘要 |
A novel multi-unit ribozyme is provided which is capable of selectively cleaving the mRNA transcript of a hybrid oncogene resulting from a chromosomal translocation. Specialized delivery vehicles such as liposomes, and growth factor conjugates for cellular uptake by receptor-mediated endocytosis, are also described. The multi-unit ribozyme is used for the treatment of neoplasms characterized by expression of the oncogene. In one embodiment, a multi-unit ribozyme is provided which cleaves the mRNA transcript of Philadelphia chromosome-positive cells, thereby blocking production of the tumorigenic p210bcr-abl fusion protein. |
申请公布号 |
AU7720394(A) |
申请公布日期 |
1995.04.03 |
申请号 |
AU19940077203 |
申请日期 |
1994.08.31 |
申请人 |
TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIO |
发明人 |
LANCE H LEOPOLD;SCOTT K SHORE;MOOLE V. R REDDY;E. PREMKUMAR REDDY |
分类号 |
A61K38/00;A61K47/48;A61K48/00;C12N15/113 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|