发明名称 |
Method to enhance trombomodulin apc generation using cationic proteins |
摘要 |
A method of inhibiting blood coagulation in a patient is provided. This method involves administering to the patient an effective anticoagulant amount of a cationic protein; wherein the cationic protein has an isoelectric point of at least about 7.4, and is capable of enhancing the production of activated protein C by a thrombomodulin-thrombin complex by a factor of at least about two. A particularly preferred cationic protein is purified Platelet Factor 4. |
申请公布号 |
AU7643294(A) |
申请公布日期 |
1995.04.03 |
申请号 |
AU19940076432 |
申请日期 |
1994.09.06 |
申请人 |
REGENTS OF THE UNIVERSITY OF MINNESOTA |
发明人 |
ARNE SLUNGARD |
分类号 |
A61K38/16;A61K38/17;A61K38/19 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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