发明名称 |
N-(3-PYRROLIDINYL)BENZAMIDE DERIVATIVE |
摘要 |
An N-(3-pyrrolidinyl)benzamide derivative represented by general formula (I) having a selective and potent affinity for dopamine D3 receptors and/or dopamine D4 receptors, a pharmaceutically acceptable salt thereof, and dopamine D3 receptor and/or dopamine D4 receptor antagonists, wherein R<1> represents halogen; R<2> represents lower alkoxy; R<3> represents hydrogen or lower alkyl; A represents a single bond or lower alkylene; ring B represents substituted or unsubstituted: 1) saturated or unsaturated 3- to 8-membered monocyclic hydrocarbon groups or 4- to 16-membered fused bicyclic hydrocarbon groups; 2) saturated or unsaturated 3- to 8-membered heterocyclic group or 6- to 16-membered fused bicyclic heterocyclic group each containing one or two of the heteroatoms comprising nitrogen, sulfur and oxygen, 3) saturated or unsaturated 4- to 16-membered bi- or tricyclic bridged hydrocarbon group, or 4) saturated or unsaturated 6- to 16-membered bi- or tricyclic bridged heterocyclic group each containing one or two of the heteroatoms comprising nitrogen, sulfur and oxygen; and R<4> represents 1) phenyl; 2) halogenated or nonhalogenated 3- to 8-membered monocyclic saturated hydrocarbon group; or 3) lower alkyl, halogenated lower alkyl or lower alkenyl; provided with group -A-B represents benzyl, R<4> represents a group other than methyl. This compound is useful as a psychotropic agent having little or no side effects such as extrapyramidal syndrome.
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申请公布号 |
WO9508533(A1) |
申请公布日期 |
1995.03.30 |
申请号 |
WO1994JP01547 |
申请日期 |
1994.09.20 |
申请人 |
YAMANOUCHI PHARMACEUTICAL CO., LTD.;OHMORI, JUNYA;MAENO, KYOICHI;HIDAKA, KAZUYUKI;NAKATO, KAZUHIRO;SAKAMOTO, SHUICHI;TSUKAMOTO, SHIN-ICHI |
发明人 |
OHMORI, JUNYA;MAENO, KYOICHI;HIDAKA, KAZUYUKI;NAKATO, KAZUHIRO;SAKAMOTO, SHUICHI;TSUKAMOTO, SHIN-ICHI |
分类号 |
C07D207/14;C07D207/32;C07D207/335;C07D401/06;C07D403/06;C07D405/06;C07D409/06;C07D413/06;(IPC1-7):C07D207/14;C07D405/04;C07D409/04;C07D451/04;A61K31/40;A61K31/44;A61K31/46 |
主分类号 |
C07D207/14 |
代理机构 |
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地址 |
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