COMPOSITIONS AND METHODS FOR MODULATING -g(b)-AMYLOID.

摘要

Compositions and methods are provided for the modulation of abnormal expression of beta-amyloid. Oligonucleotides are provided which are specifically hybridizable with RNA or DNA encoding beta-amyloid. Oligonucleotides specifically hybridizable with a translation initiation site, codon 717, codon 670 or codon 671 of betaAPP are provided. Such oligonucleotides can be used for diagnostics as well as for research purposes. Methods are also disclosed for modulating beta-amyloid expression in cells and tissues using the oligonucleotides provided, and for specific modulation of expression of the mutant betaAPP gene. Methods for diagnosis, detection and treatment of diseases associated with abnormal betaAPP expression are also disclosed.