7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same

摘要

A method is provided for preparing carboxylic acid intermediates of the structure <IMAGE> wherein an aldehyde of the structure <IMAGE> is prepared and subjected to a Horner-Emmons reaction to form the ester of the structure <IMAGE> and the ester is hydrogenated to the carboxylic acid which may be used in making the final anti-thrombotic-anti-vasospastic compounds.