Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate

摘要

The invention is directed to the crystalline isopropyl alcohol solvate of loracarbef, and also is directed to a process for the preparation of the crystalline monohydrate form of the compound of formula (I) <IMAGE> (I) which includes exposing the crystalline isopropyl solvate form of the compound of formula (I) to a temperature of between about 50 DEG and 90 DEG C. and a relative humidity of between about 60 to about 100%.