发明名称 |
Stable parenteral compositions of vinblastine or vincristine |
摘要 |
The invention relates to novel, parenterally useful, stable aqueous pharmaceutical compositions, mainly injectable solutions containing a bis-indole alkaloid. The compositions contain the zinc complex of a bis-indole alkaloid, preferably vincristine, vinblastine or 5'-nor-dihydrovinblastine together with a bivalent metal gluconate and a preserving agent dissolved in a mono- or polyhydric alcohol. The invention further relates to a process for the preparation of the above compositions. The composition according to the invention can be utilized for the parenteral administration of bis-indole alkaloids in the cancer chemotherapy.
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申请公布号 |
US5397784(A) |
申请公布日期 |
1995.03.14 |
申请号 |
US19900608481 |
申请日期 |
1990.11.02 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR RT. |
发明人 |
GAZDAG, MARIA;SZEPESI, GABOR;NAGY, TAKACSI;PAPP, SZIKLA Z.;NAGY, LASZLO;KISS, EVA E.;ZSOLDOS, BOBJAK M. |
分类号 |
A61K9/08;A61K9/00;A61K31/475;A61K47/14;A61K47/26;A61P35/00;(IPC1-7):A61K31/44 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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