| 摘要 |
Phenols and phenol derivatives having the general structural formula (I) are used to produce medicaments with fibrinogen-reducing effect. Also disclosed are new phenols and phenol derivatives, a process for producing the same and medicaments containing these compounds. In the formula, R stands for hydrogen or one to three substituents selected independently from each other from the halogen, C1-C4-alkyl, C1-C4-alkoxy, hydroxy, cyano oder trifluoromethyl series; B stands for a saturated or unsaturated alkylene chain with up to 6 C atoms substituted or not by one or two methyl groups in any desired position. One of the saturated C atoms may be substituted by an oxygen atom or by one of the groups >NH, >C=O oder >CH-OH, and two adjacent saturated C atoms may also be substituted together by a group -CONH- or -NHCO-. X is in a meta- or para-position in relation to B and stands for the following groups: a hydroxy group or a C1-C4-alkylurethane or substituted or non-substituted phenylurethane group derived from the hydroxy group; an unbranched or a C1-C6-alkyloxy, omega-hydroxy-C2-C6-alkyloxy, omega-halogen-C2-C6-alkyloxy or omega-cyano-C1-C6-alkyloxy group substituted by one or two methyl groups in any desired position; a C1-C4-alkyl urethane, a substituted or non-substituted phenyl urethane, phosphoric acid ester, aliphatic carboxylic acid ester grouping or a possibly substituted benzoic acid ester grouping derived from the omega-hydroxy-C2-C6-alkoxy group; an aminocarbonyl-C1-C6-alkoxy or a N-hydroxy-aminocarbonyl-C1-C6-alkoxy group; carboxymethoxy, 1-carboxy-ethoxy, 1-carboxy-propyloxy or 3-carboxy-propyloxy; the residue -O-C-(CH3)2-CH2-O-CO-(CH2)2-COOH; the possibly substituted benzoyloxy residue. |
