| 摘要 |
<p>The present invention provides a nucleic acid molecule having a nucleotide sequence encoding human MOG, an autoantigen related to demyelinating autoimmune diseases. The present invention also provides recombinantly produced human MOG or antigenic fragments. Antigenic fragments of MOG, which can be prepared synthetically, represent T-cell epitopes of human MOG. Human MOG and fragments thereof are useful for diagnosing and treating autoimmune diseases. Further, methods of screening for, and developing therapeutics useful in the treatment of autoimmune diseases are also disclosed.</p> |
