| 摘要 |
Phenacyl-type esters of PGE2, PGE1, and 13,14-dihydro-PGE1 and their 15-methyl, 16,16-dimethyl, and 17-phenyl analogs, including the respective 15(R)epimers, are disclosed, represented by the formula <IMAGE> wherein M is <IMAGE> wherein R3 is hydrogen or methyl; wherein Q is <IMAGE> (1) wherein each of R4 and R5 is hydrogen or methyl, being the same or different, or <IMAGE> (2) wherein the moiety-CtH2t- represents a valence bond or alkylene of one to 10 carbon atoms, inclusive, with one to 7 carbon atoms, inclusive, between <IMAGE> and the phenyl ring; wherein R1 is phenyl, p-bromophenyl, p-biphenylyl, p-nitrophenyl, p-benzamidophenyl, or 2-naphthyl; wherein R2 is hydrogen or benzoyl; and wherein (a) X is -CH2CH2- or trans-CH=CH- and Y is -CH2CH2-, or (b) X is trans-CH=CH- and Y is cis-CH=CH-. The products are useful for the same pharmacological and medical purposes as the corresponding prostaglandins and analogs, and are also useful as a means for obtaining highly purified products. |
