| 发明名称 |
Oncoprotein protein kinase |
| 摘要 |
An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD or 55 kD as determined by reducing SDS-PAGE, having serine and theonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites. |
| 申请公布号 |
AU7338094(A) |
申请公布日期 |
1995.02.20 |
| 申请号 |
AU19940073380 |
申请日期 |
1994.07.18 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL |
发明人 |
MICHAEL KARIN;ROGER DAVIS;MASAHIKO HIBI;ANNING LIN;BENOIT DERIJARD |
| 分类号 |
G01N33/573;A61K31/00;A61K38/00;A61K39/395;A61P5/40;A61P9/08;A61P9/10;A61P25/04;A61P29/00;A61P31/00;A61P31/12;A61P35/00;A61P35/02;A61P37/00;A61P37/02;A61P43/00;C07H21/04;C07K14/705;C07K14/82;C07K16/30;C07K16/32;C07K16/40;C12N5/10;C12N9/12;C12N15/02;C12N15/09;C12N15/54;C12P21/08;C12Q1/68;G01N33/574;G01N33/577 |
主分类号 |
G01N33/573 |
| 代理机构 |
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