Azalicyclooctane derivatives as anti-arrhythmic agents

摘要

PCT No. PCT/EP94/02299 Sec. 371 Date Feb. 14, 1996 Sec. 102(e) Date Feb. 14, 1996 PCT Filed Jul. 11, 1994 PCT Pub. No. WO95/03301 PCT Pub. Date Feb. 2, 1995A compound of formula (I) or a salt thereof, or a solvate thereof: (I) wherein B represents a C1-4 n-alkylene group wherein each carbon is optionally substituted by a C1-6 alkyl group; Z represents a bond, CH2, (CH2)2 or X-CH2-CH2 wherein X represents O or S; D represents CO, SO2, NH-CO or NH-SO2; T represents a bond and U represents CH2 or T represents CH2 and U represents a bond; Q represents aryl, aralkyl, aralkenyl or aralkynyl, wherein the aryl moiety may be unsubstituted or substituted with 1 to 5 substituents selected from the list consisting of nitre, halogen, alkylsulfonamido, acylamido, 1H-imidazolyl, alkyl or haloalkyl, or Q represents substituted or unsubstituted: furanyl, pyranyl, thienyl, thiazolyI, imidazolyl, triazolyl or the benzo fused equivalents or furanyl, pyranyl, thienyl, thiazolyl, 1H-imidazolyl, or triazolyl, indolyl, oxoindolyl, indenyl, isoindenyl, indazolyl, indolizinyl or pyridinyl or cycloalkyl optionally fused to an aryl group; R1, R2, and R3 each independently represents H, alkyl, OH or alkoxy or, if attached to adjacent carbon atoms, any two of R1, R2, and R3 together with the carbon atoms to which they are attached may form a fused heterocyclic ring of five or six atoms wherein one, two or three of the said atoms are oxygen or nitrogen; Ar represents substituted or unsubstituted aryl, wherein the optional substituents are the above defined R1, R2, and R3 or Ar represents a substituted or unsubstituted heteroaryl group; a process for the preparation of such a compound and the use of such a compound in medicine.