| 摘要 |
A piperazine derivative represented by general formula (I) and a salt thereof, wherein B represents phenyl or pyridyl; m represents an integer of 2 or 3; p represents an integer of 1 or 2; R<1> represents hydrogen or halogen; and A represents -COOR<2>, -Y-(CH2)n-R<3>, (a), (b) or (c), wherein R<2> represents hydrogen or lower alkyl, Y represents sulfur, oxygen, NH or <- CONH- wherein <- represents a linkage with (CH2)m; n represents an integer of 0 to 3; R<3> represents cyano, amino, hydroxymethyl, 1H-tetrazolyl, 1-imidazolylcarbonyl, etc.; X represents CH or nitrogen; and R<6> represents hydrogen or lower alkoxy. The compound has potent antihistaminic and antiallergic activities and high safety, and hence is excellent as antihistaminic, antiallergic and antiasthmatic drugs. <CHEM> |
