Ipriflavone and pharmaceutical compositions and their use for bone defect substitution.

摘要

The invention relates to the use of Ipriflavone (7-isopropoxyisoflavone) and combinations thereof with porous hydroxylapatite and/or tricalcium phosphate for the substitution of bone defects having pathologically developed or being artificially established, as well as to compositions containing these active ingredients and their preparation. In the combinations of the invention, the mass ratio A/B of porous hydroxylapatite and/or tricalcium phosphate (A) to Ipriflavone (B) is preferably 1:9 to 9:1 and most preferably 1:1. The components are preferably present in the form of discrete granules. Preferably, the Ipriflavone is applied onto the surface of the porous hydroxylapatite and/or tricalcium phosphate. The compositions of the invention lead to an accelerated bone formation.