Nucleic acid sequences vectors containing them pharmaceutical compositions and therapeutic uses

摘要

PCT No. PCT/FR94/00714 Sec. 371 Date Dec. 28, 1995 Sec. 102(e) Date Dec. 28, 1995 PCT Filed Jun. 15, 1994 PCT Pub. No. WO94/29446 PCT Pub. Date Dec. 22, 1994The present invention relates to nucleic acid sequences encoding intracellular binding proteins. More particularly, the nucleic acid comprises a gene coding for an intracellular single chain antibody specific for a ras oncogene under the control of a promoter, the antibody is functional in mammalian cells, and inhibits the transformation of cells that express a ras oncogene.