发明名称 |
PIPERAZINE DERIVATIVES AS alpha 1A-ADRENERGIC RECEPTOR ANTAGONISTS |
摘要 |
There are disclosed compounds of general formula (I). Y is a linking group, chosen from a wide range, but including -COO-, -CH2COO-, -CONH-, -CON(CH3)-, -CH2CONH-, -SO2NH-, -SO2N(CH3)- and -PO(OC2H5)NH-. W is an alkylene chain. A is a substituted phenyl group or a benzofuran or benzodioxan group. R and R1 may have many values, but R is preferably a bulky group. These compounds and their prodrugs, enantiomers, diastereoisomers, N-oxides and pharmaceutically acceptable salts block alpha 1A-adrenergic receptors and are thus useful for the prevention of contractions of the prostate, urethra and lower urinary tract, without affecting blood pressure. |
申请公布号 |
WO9504049(A1) |
申请公布日期 |
1995.02.09 |
申请号 |
WO1994EP02437 |
申请日期 |
1994.07.22 |
申请人 |
RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A.;RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPAN;LEONARDI, AMEDEO;MOTTA, GIANNI;RIVA, CARLO;TESTA, RODOLFO |
发明人 |
LEONARDI, AMEDEO;MOTTA, GIANNI;RIVA, CARLO;TESTA, RODOLFO |
分类号 |
C07D295/12;A61K31/38;A61K31/381;A61K31/495;A61K31/496;A61P25/02;A61P43/00;C07D261/08;C07D261/10;C07D263/32;C07D263/34;C07D277/20;C07D277/22;C07D277/32;C07D295/088;C07D295/13;C07D295/20;C07D307/82;C07D319/18;C07D333/08;C07F9/6509 |
主分类号 |
C07D295/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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