Cell growth factor receptors

摘要

The invention relates to a method of screening a substance for potential utility as a therapeutic agent in the treatment of cancer which comprises providing a standard system in which a protein tyrosine kinase or an active fragment thereof is able to develop a measurable effect, allowing the protein tyrosine kinase to develop that effect in the presence and absence of the said substance and measuring that effect, ability to produce significant inhibition of the effect being taken as an indication of potential utility as a therapeutic agent, wherein the protein tyrosine kinase is characterised by the amino acid sequence of SEQ ID NO. 1 or an amino acid sequence showing a significant degree of homology thereto. The invention also relates to a therapeutic agent thus identified, to a method for detecting the protein tyrosine kinase and an enzyme substrate complex comprising the protein tyrosine kinase and a therapeutic agent capable of modulating the activity of the protein tyrosine kinase.