发明名称 |
Carbohydrate receptor for bacteria and method for use thereof |
摘要 |
A carbohydrate receptor for pathogenic bacteria is a purified carbohydrate compound that is a member selected from the group consisting of fucosyl-asialo GM1, asialo GM1, and asialo GM2. The receptor can be included in a composition having a pharmaceutically acceptable carrier. The receptor may be used for purifying, detecting, or removing bacteria from diseased tissue. The structure of the receptor is N-acetylagalctosamine-beta-1-4-galactose-beta-1-4-glucose, abbreviated GalNAc beta 1-4Gal beta 1-4Glc. The receptor is present in human and animal tissues as complex molecule and can serve as the attachment site for bacterial infection. For example, fucosyl-asialo GM1, asialo GM1, and asialo GM2 are three biological molecules which occur in cell membranes and contain the carbohydrate receptor.
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申请公布号 |
US5386027(A) |
申请公布日期 |
1995.01.31 |
申请号 |
US19930060134 |
申请日期 |
1993.05.13 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES |
发明人 |
KRIVAN, HOWARD C.;GINSBURG, VICTOR;ROBERTS, DAVID D. |
分类号 |
A61K31/70;G01N33/569;(IPC1-7):C08B37/00;A61K39/02 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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