Molecules with antibody combining sites that catalyze carbocyclic ring formation from 5,6-ethylenically unsaturated sulfonate molecules

摘要

The present invention contemplates monoclonal antibody combining site-containing molecules that catalyze the formation of a 6-membered ring compound from a 5,6-ethylenically-unsaturated-1-sulfonate substrate. The catalytic molecules bind to the substrate molecule as well as to a structural analog of the substrate that is a piperidine N-oxide whose nitrogen atom is in the same relative position in that ring as the sulfonate-bearing carbon atom of the open-chain substrate. A hybridoma that secretes the catalytic molecules and a process for forming a 6-membered ring compound that utilizes the catalytic molecules are also disclosed.