发明名称 |
PYRIDAZINES AS INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITORS. |
摘要 |
Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: <CHEM> wherein R1 is halogen, oxygen linked leaving group including aromatic ether, aromatic ester, alkyl sulfonate, aryl sulfonate, alkyl phosphonate, aryl phosphonate, alkyl phosphate or aryl phosphate; R2 is OR5, NH(CHR5)m-COOR5, NH(CHR5)mCON(R5)R6, N(R5)R6 or NH(CHR5)nOH; R3 is H or alkyl; R4 is H, substituted or unsubstituted aryl, heteroaryl or alkyl; R5 and R6 are independently H, lower alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl or lower cycloalkyl; m = 1-6; and n = 2-6. pharmaceutical compositions containing the compounds; and a method for inhibiting interleukin-1 beta protease activity in a mammal utilizing the compounds and compositions. |
申请公布号 |
EP0628550(A3) |
申请公布日期 |
1995.01.18 |
申请号 |
EP19940201597 |
申请日期 |
1994.06.04 |
申请人 |
STERLING WINTHROP INC. |
发明人 |
DOLLE, ROLAND E., C/O STERLING WINTHROP INC.;HOYER, DENTON W., C/O STERLING WINTHROP INC.;SCHMIDT, STANLEY J., C/O STERLING WINTHROP INC.;ROSS, TINA M., C/O STERLING WINTHROP INC.;RINKER, JAMES M., C/O STERLING WINTHROP INC.;ATOR, MARK A., C/O STERLING WINTHROP INC. |
分类号 |
A61K31/50;A61P29/00;A61P35/00;A61P43/00;C07D237/24;C07D401/04;C07D403/04 |
主分类号 |
A61K31/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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