| 摘要 |
In accordance with the present invention, there are provided novel G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of </= 10 nM of CRF occupy >/= 50 % of the binding sites of said receptor protein. Nucleic acid sequences encoding such receptors, assays employing same, as well as antibodies derived therefrom, are also disclosed. Invention CRF-Rs can be employed in a variety of ways, such as, for example, in bioassays, for production of antibodies thereto, in therapeutic compositions containing such proteins and/or antibodies.
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| 申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES;PERRIN, MARILYN, H.;CHEN, RUOPING;LEWIS, KATHY, A.;VALE, WYLIE, W., JR.;DONALDSON, CYNTHIA, J. |
发明人 |
PERRIN, MARILYN, H.;CHEN, RUOPING;LEWIS, KATHY, A.;VALE, WYLIE, W., JR.;DONALDSON, CYNTHIA, J. |
