AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS

摘要

The invention relates to novel compounds of formula (I): H<SUB>2</SUB>N-CH(R<SUB>1</SUB>)-CH<SUB>2</SUB>-S-S- CH<SUB>2</SUB>-CH(R<SUB>2</SUB>)-CONH-R<SUB>5</SUB>, wherein R<SUB>1</SUB> is a hydrocarbon chain, phenyl or benzyl radical, methylene radical substituted by a 5 or 6 atom heterocycle; R<SUB>2</SUB> is a phenyl or benzyl radical, a 5 or 6 atom aromatic heterocycle, methylene group substituted by a 5 or 6 atom heterocycle; R<SUB>5</SUB> is a CH(R<SUB>3</SUB>)-COOR<SUB>4</SUB> radical, wherein R<SUB>3</SUB> is hydrogen, an OH or OR group, a saturated hydrocarbon group, a phenyl or benzyl radical and OR<SUB>4</SUB> is hydrophile ester, or 5 or 6 membered heterocycle comprising several heteroatoms selected from a group consisting of nitrogen, sulphur and oxygen, with at least two nitrogene atoms, wherein said heterocycle is substitutable by an alkyl C<SUB>1</SUB>-C<SUB>6</SUB>, phenyl or benzyl radical. The use of the inventive compounds in the form of drugs, a pharmaceutical composition comprising said compounds, a pharmaceutically acceptable excipient, the use in conjunction of at least one type of cannabinoid derivative for potentiating the analgesic and antidepressant effect of the novel compounds of formula (I) and/or morphine or the derivatives thereof are also disclosed.