Quinazoline derivatives and medicaments containing them

摘要

The invention relates to quinazoline derivatives of the formula I <IMAGE> in which R is a phenyl ring or a carbocyclic ring having 7-15 C atoms or a heterocyclic ring system in each case having 5 or 6 ring atoms and these are optionally mono- or polysubstituted by C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylmercapto, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-alkylcarbonylamino, hydroxyl, nitro, halogen, trifluoromethyl or azido, R<1> is a hydrogen atom, an aliphatic radical having 1-6 C atoms or C1-C6-alkoxy, C1-C6-alkylmercapto, C1-C6-alkylsulphinyl, C1-C6-alkylsulphonyl, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, sulphonamido, C1-C6-alkoxycarbonyl, carboxyl, halogen, hydroxyl, nitro, cyano or azido, R<2> is C1-C8-alkyl, C2-C8-alkenyl, C3-C8-cycloalkyl, C3-C8-cycloalkenyl, where the alkyl or alkenyl radicals can optionally be substituted by fluorine, chlorine, hydroxyl and mercapto or interrupted by an oxygen or sulphur atom, R<3> is hydrogen or a C1-C6-alkyl group which can be substituted by one, two or three halogen atoms, X is an oxygen or sulphur atom, Y is a nitrogen atom or CR<1>, and their tautomers, enantiomers, diastereomers and physiologically tolerable salts.