ANTI-CD3 ANTIBODY-AMINODEXTRAN CONJUGATES FOR INDUCTION OF T-CELL ACTIVATION AND PROLIFERATION

摘要

The invention describes the use of novel aminodextran compounds containing about 5-20 % by weight amine groups to bind a plurality of monoclonal antibodies. The resulting antibody-aminodextran compounds may be used to induce the activation and proliferation of selected mammalian cells. Specific examples are given using an anti-CD3 monoclonal antibody conjugated to aminodextrans containing about 5 % and 16 %, respectively, by weight amine groups as an agent for inducing the activation and proliferation of T cells.