发明名称 |
HYDROXYQUINOLONE DERIVATIVES |
摘要 |
A class of 4-hydroxy-2-(1H)-quinolone derivatives, substituted at the 3-position by an optionally substituted aryl substituent, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA receptor antagonist. |
申请公布号 |
LTIP491(A) |
申请公布日期 |
1994.11.25 |
申请号 |
LTIP491 |
申请日期 |
1993.04.19 |
申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
KULAGOWSKI,JANUSZ J.;LEESON,PAUL D.;MAWER,IAN MICHAEL;ROWLEY,MICHAEL |
分类号 |
A61K31/47;A61K31/535;A61P1/08;A61P25/08;A61P25/28;A61P25/30;C07D215/22;C07D401/10;C07D401/12;C07D403/10;C07D405/04;C07D405/10;C07D405/12;C07D409/10;C07D409/12 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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