发明名称 |
METHODS AND COMPOSITIONS FOR DETECTING AND TREATING MYCOBACTERIAL INFECTIONS USING AN INHA GENE |
摘要 |
The embodiments of the invention are based upon the identification and characterization of genes that determine mycobacterial resistance to the antibiotic isoniazid (INH) and its analogs. These genes, termed inhA, encode a polypeptide, InhA, that is the target of action of mycobacteria for isoniazid. The sequences of wild-type INH-sensitive as well as allelic or mutant INH-resistant inhA genes and their operons are provided. Also provided are isolated InhA polypeptides of both INH-resistant and the INH-sensitive types. |
申请公布号 |
CA2162868(A1) |
申请公布日期 |
1994.11.24 |
申请号 |
CA19942162868 |
申请日期 |
1994.05.12 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY;AGRESEARCH, NEW ZEALAND PASTORAL AGRICULTURE RESEARCH INSTITUTE LTD. |
发明人 |
JACOBS, WILLIAM R., JR.;BANERJEE, ASESH;WILSON, THERESA MARY;DE LISLE, GEOFFREY WILLIAM;COLLINS, DESMOND MICHAEL |
分类号 |
C12N15/09;A61K8/00;A61K31/70;A61K38/00;A61K39/04;A61P31/04;A61Q17/00;C07H21/04;C12N1/21;C12N9/02;C12N9/08;C12P7/40;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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