发明名称 |
THROMBIN INHIBITORS |
摘要 |
4-substituted cyclohexylamine derivatives which are thrombin catalytic site inhibitors and which are useful as anticoagulants. These compounds show selectivity for thrombin over other trypsin-like enzymes and have oral bioavailabilty. They have formula (a) or (b), for exmple (c).
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申请公布号 |
CA2159834(A1) |
申请公布日期 |
1994.11.10 |
申请号 |
CA19942159834 |
申请日期 |
1994.04.25 |
申请人 |
MERCK & CO., INC. |
发明人 |
VEBER, DANIEL F.;LEWIS, S. DALE;SHAFER, JULES A.;FENG, DONG-MEI;NUTT, RUTH F.;BRADY, STEPHEN F. |
分类号 |
C07D211/36;A61K31/16;A61K31/19;A61K31/215;A61K31/40;A61K31/445;A61K38/00;A61P7/02;A61P43/00;C07C237/10;C07C271/22;C07D207/16;C07D211/60;C07K5/02;C07K5/06;C07K5/065;C07K5/087;(IPC1-7):C07K5/08;A61K38/05;A61K38/06 |
主分类号 |
C07D211/36 |
代理机构 |
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主权项 |
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地址 |
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