ANTIVIRAL GUANOSINE-RICH OLIGONUCLEOTIDES

摘要

A method and composition for treating viral infection in vitro and in vivo using guanosine-rich oligonucleotides. The oligonucleotides have sufficient guanosine to form a guanosine tetrad. They can be composed of at least about 40 % guanosine nucleotides. Also provided are oligonucleotides of at least two runs of at least two guanosines. Also provided are guanosine-rich oligonucleotides and methods for treating viral infections in humans and a method for designing guanosine-rich oligonucleotides having anti-viral activity.