4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors.

摘要

The invention concerns ether derivatives of the formula I Q<1>-X-Ar-Q<2> I wherein Q<1> is an optionally substituted 9-, 10- or 11-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur; X is oxy, thio, sulphinyl or sulphonyl; Ar is optionally substituted phenylene, pyridinediyl, pyrimidinediyl, thiophenediyl, furandiyl, thiazolediyl, oxazolediyl, thiadiazolediyl or oxadiazolediyl; and Q<2> is selected from the groups of the formulae II and III:- <CHEM> wherein R<1> is hydrogen, (2-5C)alkanoyl or optionally substituted benzoyl; R<2> is (1-4C)alkyl; and R<3> is hydrogen or (1-4C)alkyl; or R<2> and R<3> are linked to form a methylene, vinylene, ethylene or trimethylene group; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.