发明名称 |
NOVEL SULFONIC ACIDE DERIVATIVE AND MEDICINAL USE THEREOF. |
摘要 |
<p>A sulfonamide derivative represented by general formula (I) and a thromboxane A2 receptor antagonist containing the same as the active ingredient, wherein R1 represents (i) -COOR2 wherein R2 represents (1) hydrogen, (2) a pharmacologically acceptable cation, or (3) a C1-C14 alkyl, or (ii) -C(=O)-R3 wherein R3 represents a C1-C4 alkyl; A represents (i) -(CH2)n -wherein n represents an integer of 0 to 3, (ii) -CH=CH-, or (iii) -O-C(R4)(R5)- wherein R4 and R5 may be the same or different from each other and each represents (1) hydrogen or (2) a C1-C4 alkyl, and W represents -NH- or -O-. This compound has an excellent thromboxane A2 receptor antagonism and hence can be used as a highly active and persistent thromboxane A2 receptor antagonist. <CHEM></p> |
申请公布号 |
EP0621273(A1) |
申请公布日期 |
1994.10.26 |
申请号 |
EP19930919681 |
申请日期 |
1993.09.17 |
申请人 |
TORAY INDUSTRIES, INC. |
发明人 |
OHNO, KIYOTAKA;OHTAKE, ATSUSHI;NISHIO, SHINTARO;HOSHI, KAZUHIRO;TSUKAMOTO, SHUNJI |
分类号 |
C07D307/93;(IPC1-7):C07D307/77;A61K31/34 |
主分类号 |
C07D307/93 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|